This study aims to develop a science-based practical guide for inquiry in measurement subjects and heat. This research uses a research and development approach in which adjusted into three stages are employed, namely collecting information, planning, and developing a preliminary product. The instruments used to collect data in this study are information observation sheets, development plan sheets and product validation questionnaires. Based on the results of the study, it can be concluded that IPA practicum was developed based on inquiry in the measurement and heat materials. Validation result on the aspect of content feasibility shows that the inquiry-based science practical guide is feasible to use with a feasibility percentage of 71.87%. While the validation result on the feasibility aspects of the presentation shows that the inquiry-based science practical guide is suitable to use with a feasibility percentage of 75%.